Dataset Information
SARS-CoV-2 infection in human adult lung alveolar stem cells
Ontology highlight
ABSTRACT:
SUBMITTER: Joo-Hyeon Lee
PROVIDER: EMPIAR-10533 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Cell stem cell 20201021 6
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the cause of a present pandemic, infects human lung alveolar type 2 (hAT2) cells. Characterizing pathogenesis is crucial for developing vaccines and therapeutics. However, the lack of models mirroring the cellular physiology and pathology of hAT2 cells limits the study. Here, we develop a feeder-free, long-term, three-dimensional (3D) culture technique for hAT2 cells derived from primary human lung tissue and investigate infe ...[more]
