Dataset Information
CryoEM structure of the apo-CGRP receptor in a detergent micelle
Ontology highlight
ABSTRACT:
SUBMITTER: Radostin Danev
PROVIDER: EMPIAR-10668 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.
Science (New York, N.Y.) 20210218 6538
G protein-coupled receptors (GPCRs) are key regulators of information transmission between cells and organs. Despite this, we have only a limited understanding of the behavior of GPCRs in the apo state and the conformational changes upon agonist binding that lead to G protein recruitment and activation. We expressed and purified unmodified apo and peptide-bound calcitonin gene-related peptide (CGRP) receptors from insect cells to determine their cryo-electron microscopy (cryo-EM) structures, and ...[more]