Human WLS in complex with WNT8A
Ontology highlight
ABSTRACT:
SUBMITTER: Filippo Mancia
PROVIDER: EMPIAR-10699 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.
Nygaard Rie R Yu Jia J Kim Jonathan J Ross Daniel R DR Parisi Giacomo G Clarke Oliver B OB Virshup David M DM Mancia Filippo F
Cell 20201223 1
Wnts are evolutionarily conserved ligands that signal at short range to regulate morphogenesis, cell fate, and stem cell renewal. The first and essential steps in Wnt secretion are their O-palmitoleation and subsequent loading onto the dedicated transporter Wntless/evenness interrupted (WLS/Evi). We report the 3.2 Å resolution cryogenic electron microscopy (cryo-EM) structure of palmitoleated human WNT8A in complex with WLS. This is accompanied by biochemical experiments to probe the physiologic ...[more]
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