Dataset Information
Human melatonin receptor MT1 - Gi1 complex
Ontology highlight
ABSTRACT:
SUBMITTER: Osamu Nureki
PROVIDER: EMPIAR-10714 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the human MT<sub>1</sub>-G<sub>i</sub> signaling complex.
Nature structural & molecular biology 20210805 8
Melatonin receptors (MT<sub>1</sub> and MT<sub>2</sub>) transduce inhibitory signaling by melatonin (N-acetyl-5-methoxytryptamine), which is associated with sleep induction and circadian rhythm modulation. Although recently reported crystal structures of ligand-bound MT<sub>1</sub> and MT<sub>2</sub> elucidated the basis of ligand entry and recognition, the ligand-induced MT<sub>1</sub> rearrangement leading to G<sub>i</sub>-coupling remains unclear. Here we report a cryo-EM structure of the hum ...[more]