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Tilt-series taken from SARS-CoV-2 infected Vero cells.

ABSTRACT:

SUBMITTER: Luiza Montenegro Mendonca

PROVIDER: EMPIAR-10753 | biostudies-other |

REPOSITORIES: biostudies-other

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Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress.

Mendonça Luiza L Howe Andrew A Gilchrist James B JB Sheng Yuewen Y Sun Dapeng D Knight Michael L ML Zanetti-Domingues Laura C LC Bateman Benji B Krebs Anna-Sophia AS Chen Long L Radecke Julika J Li Vivian D VD Ni Tao T Kounatidis Ilias I Koronfel Mohamed A MA Szynkiewicz Marta M Harkiolaki Maria M Martin-Fernandez Marisa L ML James William W Zhang Peijun P

Nature communications 20210730 1

Since the outbreak of the SARS-CoV-2 pandemic, there have been intense structural studies on purified viral components and inactivated viruses. However, structural and ultrastructural evidence on how the SARS-CoV-2 infection progresses in the native cellular context is scarce, and there is a lack of comprehensive knowledge on the SARS-CoV-2 replicative cycle. To correlate cytopathic events induced by SARS-CoV-2 with virus replication processes in frozen-hydrated cells, we established a unique mu ...[more]

PMID: 34330917

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