Dataset Information
Proton-powered peptide transporter SbmA in lipid nanodisc
Ontology highlight
ABSTRACT:
SUBMITTER: Konstantinos Beis
PROVIDER: EMPIAR-10763 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides.
Science advances 20210908 37
Antibiotic metabolites and antimicrobial peptides mediate competition between bacterial species. Many of them hijack inner and outer membrane proteins to enter cells. Sensitivity of enteric bacteria to multiple peptide antibiotics is controlled by the single inner membrane protein SbmA. To establish the molecular mechanism of peptide transport by SbmA and related BacA, we determined their cryo–electron microscopy structures at 3.2 and 6 Å local resolution, respectively. The structures show a pre ...[more]