Dataset Information
Venous puncture wound thrombi, 1, 5, 20 min post-puncture, 100 nm XY raw images, 20 nm XY pixels every 20 micons, 3 nm wide area TEM montages at selected depth
Ontology highlight
ABSTRACT:
SUBMITTER: Brian Storrie
PROVIDER: EMPIAR-10785 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates.
Communications biology 20210916 1
Primary hemostasis results in a platelet-rich thrombus that has long been assumed to form a solid plug. Unexpectedly, our 3-dimensional (3D) electron microscopy of mouse jugular vein puncture wounds revealed that the resulting thrombi were structured about localized, nucleated platelet aggregates, pedestals and columns, that produced a vaulted thrombus capped by extravascular platelet adherence. Pedestal and column surfaces were lined by procoagulant platelets. Furthermore, early steps in thromb ...[more]