Ontology highlight
ABSTRACT:
SUBMITTER: Qing Rong Fan
PROVIDER: EMPIAR-10834 | biostudies-other |
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20211201 51
The human extracellular calcium-sensing (CaS) receptor controls plasma Ca<sup>2+</sup> levels and contributes to nutrient-dependent maintenance and metabolism of diverse organs. Allosteric modulation of the CaS receptor corrects disorders of calcium homeostasis. Here, we report the cryogenic-electron microscopy reconstructions of a near-full-length CaS receptor in the absence and presence of allosteric modulators. Activation of the homodimeric CaS receptor requires a break in the transmembrane 6 ...[more]