Dataset Information
Oligomeric interactions maintain active-site structure in a non-cooperative enzyme family
Ontology highlight
ABSTRACT:
SUBMITTER: John Francis Hunt
PROVIDER: EMPIAR-10872 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Oligomeric interactions maintain active-site structure in a noncooperative enzyme family.
The EMBO journal 20220708 17
The evolutionary benefit accounting for widespread conservation of oligomeric structures in proteins lacking evidence of intersubunit cooperativity remains unclear. Here, crystal and cryo-EM structures, and enzymological data, demonstrate that a conserved tetramer interface maintains the active-site structure in one such class of proteins, the short-chain dehydrogenase/reductase (SDR) superfamily. Phylogenetic comparisons support a significantly longer polypeptide being required to maintain an e ...[more]