Dataset Information
SARS-CoV-2 spike protein S:D614G + S:A222V variant
Ontology highlight
ABSTRACT:
SUBMITTER: Jose M Carazo
PROVIDER: EMPIAR-10891 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation.
PLoS pathogens 20220711 7
The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 bindi ...[more]