Dataset Information
Tilt series and tomograms of cells expressing different non structural proteins (NSPs) of SARS-CoV-2
Ontology highlight
ABSTRACT:
SUBMITTER: Roman Polishchuk
PROVIDER: EMPIAR-10935 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle.
Nature 20220512 7915
SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication organelle to enable RNA replication<sup>1</sup>. The SARS-CoV-2 replication organelle is composed of double-membrane vesicles (DMVs) that are tethered to the endoplasmic reticulum (ER) by thin membrane connectors<sup>2</sup>, but the viral proteins and the host factors involved remain unknown. Here we identify the viral non-structural proteins (NSPs) that generate the SARS-CoV-2 replication organelle. NSP3 and NSP4 generat ...[more]
