Dataset Information
Staphylococcal self-loading helicases couple the staircase mechanism 1 with inter domain high flexibility
Ontology highlight
ABSTRACT:
SUBMITTER: Ignacio Mir Sanchis
PROVIDER: EMPIAR-10945 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Staphylococcal self-loading helicases couple the staircase mechanism with inter domain high flexibility.
Nucleic acids research 20220801 14
Replication is a crucial cellular process. Replicative helicases unwind DNA providing the template strand to the polymerase and promoting replication fork progression. Helicases are multi-domain proteins which use an ATPase domain to couple ATP hydrolysis with translocation, however the role that the other domains might have during translocation remains elusive. Here, we studied the unexplored self-loading helicases called Reps, present in Staphylococcus aureus pathogenicity islands (SaPIs). Our ...[more]