Dataset Information
Two-dimensional analysis of mouse CRP
Ontology highlight
ABSTRACT:
SUBMITTER: Yi Wu
PROVIDER: EMPIAR-10960 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Secretory quality control constrains functional selection-associated protein structure innovation.
Communications biology 20220325 1
Biophysical models suggest a dominant role of structural over functional constraints in shaping protein evolution. Selection on structural constraints is linked closely to expression levels of proteins, which together with structure-associated activities determine in vivo functions of proteins. Here we show that despite the up to two orders of magnitude differences in levels of C-reactive protein (CRP) in distinct species, the in vivo functions of CRP are paradoxically conserved. Such a pronounc ...[more]
