Dataset Information
Micrographs of ex vivo AA amyloid from renal tissue of a short hair cat deceased in a shelter
Ontology highlight
ABSTRACT:
SUBMITTER: Antonio Chaves-Sanjuan
PROVIDER: EMPIAR-11001 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter.
Nature communications 20221117 1
AA amyloidosis is a systemic disease characterized by deposition of misfolded serum amyloid A protein (SAA) into cross-β amyloid in multiple organs in humans and animals. AA amyloidosis occurs at high SAA serum levels during chronic inflammation. Prion-like transmission was reported as possible cause of extreme AA amyloidosis prevalence in captive animals, e.g. 70% in cheetah and 57-73% in domestic short hair (DSH) cats kept in zoos and shelters, respectively. Herein, we present the 3.3 Å cryo-E ...[more]