Ontology highlight
ABSTRACT:
SUBMITTER: Jonathan Firoze Fay
PROVIDER: EMPIAR-11039 | biostudies-other |
REPOSITORIES: biostudies-other
Zhang Shicheng S Chen He H Zhang Chengwei C Yang Ying Y Popov Petr P Liu Jing J Krumm Brian E BE Cao Can C Kim Kuglae K Xiong Yan Y Katritch Vsevolod V Shoichet Brian K BK Jin Jian J Fay Jonathan F JF Roth Bryan L BL
Nature structural & molecular biology 20220714 7
Serotonin receptors are important targets for established therapeutics and drug development as they are expressed throughout the human body and play key roles in cell signaling. There are 12 serotonergic G protein-coupled receptor members encoded in the human genome, of which the 5-hydroxytryptamine (5-HT)<sub>5A</sub> receptor (5-HT<sub>5A</sub>R) is the least understood and lacks selective tool compounds. Here, we report four high-resolution (2.73-2.80 Å) structures of human 5-HT<sub>5A</sub>R ...[more]