Dataset Information
Structure of SARS-CoV-2 membrane protein
Ontology highlight
ABSTRACT:
SUBMITTER: Umeharu Ohto
PROVIDER: EMPIAR-11168 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of SARS-CoV-2 membrane protein essential for virus assembly.
Nature communications 20220805 1
The coronavirus membrane protein (M) is the most abundant viral structural protein and plays a central role in virus assembly and morphogenesis. However, the process of M protein-driven virus assembly are largely unknown. Here, we report the cryo-electron microscopy structure of the SARS-CoV-2 M protein in two different conformations. M protein forms a mushroom-shaped dimer, composed of two transmembrane domain-swapped three-helix bundles and two intravirion domains. M protein further assembles ...[more]