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A molecular network of conserved factors keeps ribosomes dormant in the egg

ABSTRACT:

SUBMITTER: David Haselbach

PROVIDER: EMPIAR-11274 | biostudies-other |

REPOSITORIES: biostudies-other

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A molecular network of conserved factors keeps ribosomes dormant in the egg.

Leesch Friederike F Lorenzo-Orts Laura L Pribitzer Carina C Grishkovskaya Irina I Roehsner Josef J Chugunova Anastasia A Matzinger Manuel M Roitinger Elisabeth E Belačić Katarina K Kandolf Susanne S Lin Tzi-Yang TY Mechtler Karl K Meinhart Anton A Haselbach David D Pauli Andrea A

Nature 20230118 7945

Ribosomes are produced in large quantities during oogenesis and are stored in the egg. However, the egg and early embryo are translationally repressed<sup>1-4</sup>. Here, using mass spectrometry and cryo-electron microscopy analyses of ribosomes isolated from zebrafish (Danio rerio) and Xenopus laevis eggs and embryos, we provide molecular evidence that ribosomes transition from a dormant state to an active state during the first hours of embryogenesis. Dormant ribosomes are associated with fou ...[more]

PMID: 36653451

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