Dataset Information
Cryo-EM structures of the β3 adrenergic receptor bound to solabegron and isoproterenol
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ABSTRACT:
SUBMITTER: Osamu Nureki
PROVIDER: EMPIAR-11351 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of the β<sub>3</sub> adrenergic receptor bound to solabegron and isoproterenol.
Biochemical and biophysical research communications 20220419
The β<sub>3</sub>-adrenergic receptor (β<sub>3</sub>AR) is the most essential drug target for overactive bladder and has therapeutic potentials for the treatments of type 2 diabetes and obesity. Here, we report the cryo-electron microscopy structures of the β<sub>3</sub>AR-G<sub>s</sub> signaling complexes with the selective agonist, solabegron and the nonselective agonist, isoproterenol. Comparison of the isoproterenol-, mirabegron-, and solabegron-bound β<sub>3</sub>AR structures revealed that ...[more]