Dataset Information
Human heparan sulfate polymerase complex EXT1-EXT2
Ontology highlight
ABSTRACT:
SUBMITTER: Rebekka Wild
PROVIDER: EMPIAR-11374 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the human heparan sulfate polymerase complex EXT1-EXT2.
Nature communications 20221119 1
Heparan sulfates are complex polysaccharides that mediate the interaction with a broad range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is catalyzed by the bi-functional glycosyltransferases EXT1 and EXT2, which generate the glycan backbone consisting of repeating N-acetylglucosamine and glucuronic acid units. The molecular mechanism of heparan sulfate chain polymerization remains, however, unknown. Here, we present the cryo-electron microscopy structure o ...[more]
