Dataset Information
GPR56 (ADGRG1) 7TM domain bound to tethered agonist in complex with G protein heterotrimer
Ontology highlight
ABSTRACT:
SUBMITTER: Ximena Barros-Álvarez
PROVIDER: EMPIAR-11433 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The tethered peptide activation mechanism of adhesion GPCRs.
Nature 20220413 7907
Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-proteolysing extracellular regions that are involved in cell-cell and cell-extracellular matrix interactions<sup>1</sup>. Self cleavage within the aGPCR auto-proteolysis-inducing (GAIN) domain produces two protomers-N-terminal and C-terminal fragments-that remain non-covalently attached after receptors reach the cell surface<sup>1</sup>. Upon dissociation of the N-terminal fragment, the C-terminus of the GAIN ...[more]