Dataset Information
FMC63 scFv in complex with soluble CD19
Ontology highlight
ABSTRACT:
SUBMITTER: Joel R Meyerson
PROVIDER: EMPIAR-11441 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
CD19 CAR antigen engagement mechanisms and affinity tuning.
Science immunology 20230303 81
Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic receptors to target and lyse cancer cells. CARs bind to cell surface antigens through an scFv (binder), the affinity of which is central to determining CAR T cell function and therapeutic success. CAR T cells targeting CD19 were the first to achieve marked clinical responses in patients with relapsed/refractory B cell malignancies and to be approved by the U.S. Food and Drug Administration (FDA). We rep ...[more]