Dataset Information
5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM)
Ontology highlight
ABSTRACT:
SUBMITTER: Ximena Barros-Alvarez
PROVIDER: EMPIAR-11448 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
Neuron 20220909 19
Serotonin (5-hydroxytryptamine [5-HT]) 5-HT2-family receptors represent essential targets for lysergic acid diethylamide (LSD) and all other psychedelic drugs. Although the primary psychedelic drug effects are mediated by the 5-HT<sub>2A</sub> serotonin receptor (HTR2A), the 5-HT<sub>2B</sub> serotonin receptor (HTR2B) has been used as a model receptor to study the activation mechanisms of psychedelic drugs due to its high expression and similarity to HTR2A. In this study, we determined the cryo ...[more]