Dataset Information
Cryo electron microscopy of DNA Polymerase alpha - primase bound to SARS-CoV-2 nsp1 virulence factor
Ontology highlight
ABSTRACT:
SUBMITTER: Luca Pellegrini
PROVIDER: EMPIAR-11477 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase α-primase.
Protein science : a publication of the Protein Society 20211112 2
The molecular mechanisms that drive the infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-the causative agent of coronavirus disease 2019 (COVID-19)-are under intense current scrutiny to understand how the virus operates and to uncover ways in which the disease can be prevented or alleviated. Recent proteomic screens of the interactions between viral and host proteins have identified the human proteins targeted by SARS-CoV-2. The DNA polymerase α (Pol α)-primase compl ...[more]