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Carboxysome minishell containing CsoS1A4A and CsoS2


ABSTRACT:

SUBMITTER: Tao Ni 

PROVIDER: EMPIAR-11559 | biostudies-other |

REPOSITORIES: biostudies-other

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Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly.

Ni Tao T   Jiang Qiuyao Q   Ng Pei Cing PC   Shen Juan J   Dou Hao H   Zhu Yanan Y   Radecke Julika J   Dykes Gregory F GF   Huang Fang F   Liu Lu-Ning LN   Zhang Peijun P  

Nature communications 20230907 1


Carboxysomes are a paradigm of self-assembling proteinaceous organelles found in nature, offering compartmentalisation of enzymes and pathways to enhance carbon fixation. In α-carboxysomes, the disordered linker protein CsoS2 plays an essential role in carboxysome assembly and Rubisco encapsulation. Its mechanism of action, however, is not fully understood. Here we synthetically engineer α-carboxysome shells using minimal shell components and determine cryoEM structures of these to decipher the  ...[more]

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