Dataset Information
Movies of Glycine/Glutamate bound GluN1a-GluN2D NMDAR
Ontology highlight
ABSTRACT:
SUBMITTER: Hiroyasu Furukawa
PROVIDER: EMPIAR-11602 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Molecular cell 20221028 23
Neurotransmission mediated by diverse subtypes of N-methyl-D-aspartate receptors (NMDARs) is fundamental for basic brain functions and development as well as neuropsychiatric diseases and disorders. NMDARs are glycine- and glutamate-gated ion channels that exist as heterotetramers composed of obligatory GluN1 and GluN2(A-D) and/or GluN3(A-B). The GluN2C and GluN2D subunits form ion channels with distinct properties and spatio-temporal expression patterns. Here, we provide the structures of the a ...[more]