Dataset Information
Single particle cryo-EM dataset of mitochondrial respiratory complex I from Drosophila melanogaster
Ontology highlight
ABSTRACT:
SUBMITTER: Hannah Ruth Bridges
PROVIDER: EMPIAR-11654 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of mitochondrial respiratory complex I from <i>Drosophila melanogaster</i>.
eLife 20230109
Respiratory complex I powers ATP synthesis by oxidative phosphorylation, exploiting the energy from NADH oxidation by ubiquinone to drive protons across an energy-transducing membrane. <i>Drosophila melanogaster</i> is a candidate model organism for complex I due to its high evolutionary conservation with the mammalian enzyme, well-developed genetic toolkit, and complex physiology for studies in specific cell types and tissues. Here, we isolate complex I from <i>Drosophila</i> and determine its ...[more]