Dataset Information
Single particle cryo-EM dataset of mitochondrial complex I from Mus musculus inhibited by IACS-2858 - 2
Ontology highlight
ABSTRACT:
SUBMITTER: Hannah Ruth Bridges
PROVIDER: EMPIAR-11656 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cork-in-bottle mechanism of inhibitor binding to mammalian complex I.
Science advances 20210514 20
Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a major contributor of free energy for oxidative phosphorylation, is increasingly recognized as a promising drug target for ischemia-reperfusion injury, metabolic disorders, and various cancers. Several pharmacologically relevant but structurally unrelated small molecules have been identified as specific complex I inhibitors, but their modes of action remain unclear. Here, we present a 3.0-Å resolution cryo-electron microscopy structure o ...[more]