Dataset Information
Single particle cryo-EM dataset of Yarrowia lipolytica mitochondrial complex I
Ontology highlight
ABSTRACT:
SUBMITTER: Judy Hirst
PROVIDER: EMPIAR-11662 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation.
Nature structural & molecular biology 20200803 10
Mitochondrial complex I powers ATP synthesis by oxidative phosphorylation, exploiting the energy from ubiquinone reduction by NADH to drive protons across the energy-transducing inner membrane. Recent cryo-EM analyses of mammalian and yeast complex I have revolutionized structural and mechanistic knowledge and defined structures in different functional states. Here, we describe a 2.7-Å-resolution structure of the 42-subunit complex I from the yeast Yarrowia lipolytica containing 275 structured w ...[more]