Dataset Information
A tomogram of a concave region on the nucleus of a neutrophil
Ontology highlight
ABSTRACT:
SUBMITTER: Zhixun Li
PROVIDER: EMPIAR-11709 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Vimentin regulates nuclear segmentation in neutrophils.
Proceedings of the National Academy of Sciences of the United States of America 20231120 48
Granulocytes are indispensable for various immune responses. Unlike other cell types in the body, the nuclei of granulocytes, particularly neutrophils, are heavily segmented into multiple lobes. Although this distinct morphological feature has long been observed, the underlying mechanism remains incompletely characterized. In this study, we utilize cryo-electron tomography to examine the nuclei of mouse neutrophils, revealing the cytoplasmic enrichment of intermediate filaments on the concave re ...[more]
