Influenza A virus Hemagglutinin H5/Vietnam/1204/2004 in complex with D04 Fab
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ABSTRACT:
SUBMITTER: Ana Sofia Ferreira Ramos
PROVIDER: EMPIAR-11753 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Human naïve B cells recognize prepandemic influenza virus hemagglutinins.
Feldman Jared J Ramos Ana Sofia Ferreira ASF Vu Mya M Maurer Daniel P DP Rosado Victoria C VC Lingwood Daniel D Bajic Goran G Schmidt Aaron G AG
Science immunology 20250124 103
Understanding the naïve B cell repertoire and its specificity for potential zoonotic threats, such as the highly pathogenic avian influenza (HPAI) H5Nx viruses, may allow prediction of infection- or vaccine-specific responses. However, this naïve repertoire and the possibility to respond to emerging, prepandemic viruses are largely undetermined. Here, we profiled naïve B cell reactivity against a prototypical HPAI H5 hemagglutinin (HA), the major target of antibody responses. We found that the f ...[more]
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