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Influenza A virus Hemagglutinin H5/Vietnam/1204/2004 in complex with D04 Fab


ABSTRACT:

SUBMITTER: Ana Sofia Ferreira Ramos 

PROVIDER: EMPIAR-11753 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Human naïve B cells recognize prepandemic influenza virus hemagglutinins.

Feldman Jared J   Ramos Ana Sofia Ferreira ASF   Vu Mya M   Maurer Daniel P DP   Rosado Victoria C VC   Lingwood Daniel D   Bajic Goran G   Schmidt Aaron G AG  

Science immunology 20250124 103


Understanding the naïve B cell repertoire and its specificity for potential zoonotic threats, such as the highly pathogenic avian influenza (HPAI) H5Nx viruses, may allow prediction of infection- or vaccine-specific responses. However, this naïve repertoire and the possibility to respond to emerging, prepandemic viruses are largely undetermined. Here, we profiled naïve B cell reactivity against a prototypical HPAI H5 hemagglutinin (HA), the major target of antibody responses. We found that the f  ...[more]

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