Dataset Information
Native structure of a human GBP defense complex for cell-autonomous immunity to infection
Ontology highlight
ABSTRACT:
SUBMITTER: John David MacMicking
PROVIDER: EMPIAR-11822 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection.
Science (New York, N.Y.) 20240301 6686
All living organisms deploy cell-autonomous defenses to combat infection. In plants and animals, large supramolecular complexes often activate immune proteins for protection. In this work, we resolved the native structure of a massive host-defense complex that polymerizes 30,000 guanylate-binding proteins (GBPs) over the surface of gram-negative bacteria inside human cells. Construction of this giant nanomachine took several minutes and remained stable for hours, required guanosine triphosphate ...[more]
