Dataset Information
Cryo-EM 3D maps of the S. cerevisiae Yta7 bound to ATPgS and histone H3 tail
Ontology highlight
ABSTRACT:
SUBMITTER: Feng Wang
PROVIDER: EMPIAR-11852 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly.
The Journal of biological chemistry 20221230 2
The Saccharomyces cerevisiae Yta7 is a chromatin remodeler harboring a histone-interacting bromodomain (BRD) and two AAA+ modules. It is not well understood how Yta7 recognizes the histone H3 tail to promote nucleosome disassembly for DNA replication or RNA transcription. By cryo-EM analysis, here we show that Yta7 assembles a three-tiered hexamer with a top BRD tier, a middle AAA1 tier, and a bottom AAA2 tier. Unexpectedly, the Yta7 BRD stabilizes a four-stranded β-helix, termed BRD-interacting ...[more]