Dataset Information
High-resolution snapshots of talin auto-inhibitory states
Ontology highlight
ABSTRACT:
SUBMITTER: Izard T
PROVIDER: EMPIAR-11881 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
High-resolution snapshots of the talin auto-inhibitory states suggest roles in cell adhesion and signaling.
Nature communications 20241028 1
Talin regulates crucial cellular functions, including cell adhesion and motility, and affects human diseases. Triggered by mechanical forces, talin plays crucial roles in facilitating the formation of focal adhesions and recruiting essential focal adhesion regulatory elements such as vinculin. The structural flexibility allows talin to fine-tune its signaling responses. This study presents our 2.7 Å cryoEM structures of talin, which surprisingly uncovers several auto-inhibitory states. Contrary ...[more]
