Dataset Information
Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs
Ontology highlight
ABSTRACT:
SUBMITTER: Qing R Fan
PROVIDER: EMPIAR-11950 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Promiscuous G-protein activation by the calcium-sensing receptor.
Nature 20240417 8011
The human calcium-sensing receptor (CaSR) detects fluctuations in the extracellular Ca<sup>2+</sup> concentration and maintains Ca<sup>2+</sup> homeostasis<sup>1,2</sup>. It also mediates diverse cellular processes not associated with Ca<sup>2+</sup> balance<sup>3-5</sup>. The functional pleiotropy of CaSR arises in part from its ability to signal through several G-protein subtypes<sup>6</sup>. We determined structures of CaSR in complex with G proteins from three different subfamilies: G<sub>q< ...[more]