Dataset Information
Single-particle cryo-EM unaligned micrographs of antibody T5-1E08 in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57)
Ontology highlight
ABSTRACT:
SUBMITTER: Cerutti Gabriele
PROVIDER: EMPIAR-11952 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Distinct binding modes drive the broad neutralization profile of two persistent influenza hemagglutinin stem-specific antibody lineages.
Structure (London, England : 1993) 20250319 5
Elicitation of antibodies to the influenza hemagglutinin stem is a critical part of universal influenza vaccine strategies. While numerous broadly reactive stem antibodies have been isolated, our understanding of how these antibodies mature within the human B cell repertoire is limited. Here, we isolated and tracked two stem-specific antibody lineages over a decade in a single participant that received multiple seasonal and pandemic influenza vaccinations. Despite similar binding and neutralizat ...[more]