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Cryo-EM of (L,D)-2NapFF micelle


ABSTRACT:

SUBMITTER: Ravi Raghavbhai Sonani 

PROVIDER: EMPIAR-11974 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Atomic structures of naphthalene dipeptide micelles unravel mechanisms of assembly and gelation.

Sonani Ravi R RR   Bianco Simona S   Dietrich Bart B   Doutch James J   Draper Emily R ER   Adams Dave J DJ   Egelman Edward H EH  

Cell reports. Physical science 20240131 2


Peptide-based biopolymers have gained increasing attention due to their versatile applications. A naphthalene dipeptide (2NapFF) can form chirality-dependent tubular micelles, leading to supramolecular gels. The precise molecular arrangement within these micelles and the mechanism governing gelation have remained enigmatic. We determined, at near-atomic resolution, cryoelectron microscopy structures of the 2NapFF micelles LL-tube and LD-tube, generated by the stereoisomers (l,l)-2NapFF and (l,d)  ...[more]

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