Dataset Information
Cryo-EM Structures of human telomerase with TPP1-POT1 and telomerase H/ACA RNP
Ontology highlight
ABSTRACT:
SUBMITTER: Thi Hoang Duong Nguyen
PROVIDER: EMPIAR-11985 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
2.7 Å cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
Nature communications 20240125 1
Telomerase is a ribonucleoprotein (RNP) enzyme that extends telomeric repeats at eukaryotic chromosome ends to counterbalance telomere loss caused by incomplete genome replication. Human telomerase is comprised of two distinct functional lobes tethered by telomerase RNA (hTR): a catalytic core, responsible for DNA extension; and a Hinge and ACA (H/ACA) box RNP, responsible for telomerase biogenesis. H/ACA RNPs also have a general role in pseudouridylation of spliceosomal and ribosomal RNAs, whic ...[more]
