Dataset Information
CryoEM structure of Gq-coupled MRGPRX4 with fospropofol bound
Ontology highlight
ABSTRACT:
SUBMITTER: Jonathan Firoze Fay
PROVIDER: EMPIAR-11986 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.
Science translational medicine 20240508 746
The phosphate modification of drugs is a common chemical strategy to increase solubility and allow for parenteral administration. Unfortunately, phosphate modifications often elicit treatment- or dose-limiting pruritus through an unknown mechanism. Using unbiased high-throughput drug screens, we identified the Mas-related G protein-coupled receptor X4 (MRGPRX4), a primate-specific, sensory neuron receptor previously implicated in itch, as a potential target for phosphate-modified compounds. Usin ...[more]