Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity
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ABSTRACT:
SUBMITTER: Gunes Parlakgul
PROVIDER: EMPIAR-12017 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity.
Parlakgül Güneş G Pang Song S Artico Leonardo L LL Min Nina N Cagampan Erika E Villa Reyna R Goncalves Renata L S RLS Lee Grace Yankun GY Xu C Shan CS Hotamışlıgil Gökhan S GS Arruda Ana Paula AP
Nature communications 20240510 1
The hepatocytes within the liver present an immense capacity to adapt to changes in nutrient availability. Here, by using high resolution volume electron microscopy, we map how hepatic subcellular spatial organization is regulated during nutritional fluctuations and as a function of liver zonation. We identify that fasting leads to remodeling of endoplasmic reticulum (ER) architecture in hepatocytes, characterized by the induction of single rough ER sheet around the mitochondria, which becomes l ...[more]
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