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Cryo-EM of hMRS2-BRIL with Mg2+ [2631 multi-frame micrographs in MRC format]

ABSTRACT:

SUBMITTER: Peng Yuan 

PROVIDER: EMPIAR-12019 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Structure and function of the human mitochondrial MRS2 channel.

He Zhihui Z   Tu Yung-Chi YC   Tsai Chen-Wei CW   Mount Jonathan J   Zhang Jingying J   Tsai Ming-Feng MF   Yuan Peng P  

Nature structural & molecular biology 20241128 3

The human mitochondrial RNA splicing 2 protein (MRS2) has been implicated in Mg<sup>2+</sup> transport across mitochondrial inner membranes, thus having an important role in Mg<sup>2+</sup> homeostasis critical for mitochondrial integrity and function. However, the molecular mechanisms underlying its fundamental channel properties such as ion selectivity and regulation remain unclear. Here we present a structural and functional investigation of MRS2. Cryo-electron microscopy structures in variou  ...[more]

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