Dataset Information
Cryo-electron micrographs of human phosphorylated STAT1-DNA complexes
Ontology highlight
ABSTRACT:
SUBMITTER: Yukihiko Sugita
PROVIDER: EMPIAR-12034 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural analysis reveals how tetrameric tyrosine-phosphorylated STAT1 is targeted by the rabies virus P-protein.
Science signaling 20250318 878
Signal transducer and activator of transcription (STAT) family members mediate signaling in the Janus kinase (JAK)-STAT pathway and are activated by phosphorylation at a conserved tyrosine residue, resulting in dimerization through reciprocal interactions between the phosphotyrosine and a Src homology 2 (SH2) domain. Tyrosine-phosphorylated STAT (pY-STAT) then translocates to the nucleus to induce the expression of genes encoding antiviral proteins. Although the active and functional forms of ST ...[more]