Dataset Information
Complex structure of mouse C1ql3 with BAI3
Ontology highlight
ABSTRACT:
SUBMITTER: Yi Miao
PROVIDER: EMPIAR-12083 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3.
Communications biology 20250503 1
The adhesion-GPCR Brain-specific Angiogenesis Inhibitor-3 (BAI3) plays a crucial role in organizing synapses in the brain. However, how BAI3 engages one of its ligands, the C1q-like proteins (C1qls), remains largely unexplored. Here, we present the single-particle cryo-electron microscopy (cryo-EM) structure of the C1ql3-BAI3 complex at 2.8 Å resolution. The structure reveals a hexameric configuration, where C1ql3 forms a central homotrimer that effectively captures three BAI3 molecules. These B ...[more]
