Dataset Information
SV40 large T antigen assembly with DNA in presence of ATP.
Ontology highlight
ABSTRACT:
SUBMITTER: Taha Shahid
PROVIDER: EMPIAR-12089 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural dynamics of DNA unwinding by a replicative helicase.
Nature 20250319 8061
Hexameric helicases are nucleotide-driven molecular machines that unwind DNA to initiate replication across all domains of life. Despite decades of intensive study, several critical aspects of their function remain unresolved<sup>1</sup>: the site and mechanism of DNA strand separation, the mechanics of unwinding propagation, and the dynamic relationship between nucleotide hydrolysis and DNA movement. Here, using cryo-electron microscopy (cryo-EM), we show that the simian virus 40 large tumour a ...[more]