Dataset Information
E. coli clamp loader with primer-template DNA
Ontology highlight
ABSTRACT:
SUBMITTER: Zhi-Qiang Xu
PROVIDER: EMPIAR-12096 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli.
Nature communications 20240927 1
Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader complexes (CLCs). Detailed understanding of the mechanisms by which CLCs open and place clamps around DNA remains incomplete. Here, we present a series of six structures of the Escherichia coli CLC bound to an open or closed clamp prior to and after binding to a primer-template DNA, representing the most significant intermediates in the clamp l ...[more]