Dataset Information

SPG11-SPG15

ABSTRACT:

SUBMITTER: Ming-Yuan Su

PROVIDER: EMPIAR-12224 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Structural basis for membrane remodeling by the AP5-SPG11-SPG15 complex.

Mai Xinyi X Wang Yang Y Wang Xi X Liu Ming M Teng Fei F Liu Zheng Z Su Ming-Yuan MY Stjepanovic Goran G

Nature structural & molecular biology 20250402 8

The human spastizin (spastic paraplegia 15, SPG15) and spatacsin (spastic paraplegia 11, SPG11) complex is involved in the formation of lysosomes, and mutations in these two proteins are linked with hereditary autosomal-recessive spastic paraplegia. SPG11-SPG15 can cooperate with the fifth adaptor protein complex (AP5) involved in membrane sorting of late endosomes. We employed cryogenic-electron microscopy and in silico predictions to investigate the structural assemblies of the SPG11-SPG15 and ...[more]

PMID: 40175557

Dataset Information

SPG11-SPG15

Publications

Structural basis for membrane remodeling by the AP5-SPG11-SPG15 complex.

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2025-03-20 | PXD054972 | Pride