Dataset Information
Unaligned multi-frame micrographs of DNA polymerase theta helicase domain with AMP-PNP
Ontology highlight
ABSTRACT:
SUBMITTER: Fumiaki Ito
PROVIDER: EMPIAR-12227 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for Polθ-helicase DNA binding and microhomology-mediated end-joining.
Nature communications 20250419 1
DNA double-strand breaks (DSBs) present a critical threat to genomic integrity, often precipitating genomic instability and oncogenesis. Repair of DSBs predominantly occurs through homologous recombination (HR) and non-homologous end joining (NHEJ). In HR-deficient cells, DNA polymerase theta (Polθ) becomes critical for DSB repair via microhomology-mediated end joining (MMEJ), also termed theta-mediated end joining (TMEJ). Thus, Polθ is synthetically lethal with BRCA1/2 and other HR factors, und ...[more]