Dataset Information
Micrographs that led to the structures of INF2 on F-actin
Ontology highlight
ABSTRACT:
SUBMITTER: Nicholas Joseph Palmer
PROVIDER: EMPIAR-12243 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Mechanisms of actin filament severing and elongation by formins.
Nature 20240606 8024
Humans express 15 formins that play crucial roles in actin-based processes, including cytokinesis, cell motility and mechanotransduction<sup>1,2</sup>. However, the lack of structures bound to the actin filament (F-actin) has been a major impediment to understanding formin function. Whereas formins are known for their ability to nucleate and elongate F-actin<sup>3-7</sup>, some formins can additionally depolymerize, sever or bundle F-actin. Two mammalian formins, inverted formin 2 (INF2) and dia ...[more]