Dataset Information
Full-length mouse 5-HT3A receptor in complex with serotonin, pre-activated and open-like
Ontology highlight
ABSTRACT:
SUBMITTER: Kevin Christopher Felt
PROVIDER: EMPIAR-12265 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
GABA<sub>A</sub> Receptor-Stabilizing Protein Ubqln1 Affects Hyperexcitability and Epileptogenesis after Traumatic Brain Injury and in a Model of In Vitro Epilepsy in Mice.
International journal of molecular sciences 20220331 7
Posttraumatic epilepsy (PTE) is a major public health concern and strongly contributes to human epilepsy cases worldwide. However, an effective treatment and prevention remains a matter of intense research. The present study provides new insights into the gamma aminobutyric acid A (GABA<sub>A</sub>)-stabilizing protein ubiquilin-1 (ubqln1) and its regulation in mouse models of traumatic brain injury (TBI) and in vitro epilepsy. We performed label-free quantification on isolated cortical GABAergi ...[more]