Project description:Endometrial hyperplasia (EH), a precursor to endometrial carcinoma, poses a major threat to women’s health. Current treatments are hindered by the poor adaptability of rigid levonorgestrel (LNG)-releasing intrauterine systems. To overcome this, By physically loading LNG into the base PGC scaffold, we constructed a drug-loaded PGCL scaffold with improved therapeutic function. To elucidate the underlying molecular mechanisms of PGCL scaffold therapy, we performed high-throughput RNA sequencing on Ishikawa cells treated with PGC and PGCL scaffolds, respectively.

2026-06-30 | GSE300266 | GEO

RNA polymerase II (RNAP II)-associated factors are recruited to tRNA loci, revealing that RNAP II- and RNAP III-mediated transcriptions overlap in yeast.

Project description: Not available

| S-EPMC6699833 | biostudies-literature

Characterizing highly dynamic conformational states: The transcription bubble in RNAP-promoter open complex as an example.

Project description: Not available

| S-EPMC5750056 | biostudies-literature

TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning.

Project description: Not available

| S-EPMC5741190 | biostudies-literature

Complex scaffold remodeling in plant triterpene biosynthesis.

Project description: Not available