Dataset Information
Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-240
Ontology highlight
ABSTRACT:
SUBMITTER: Tsung-Han Chou
PROVIDER: EMPIAR-12401 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature 20240731 8023
Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental means by which neurons control their excitability and neuroplasticity<sup>1</sup>. The N-methyl-D-aspartate receptor (NMDAR) is unique among all ligand-gated channels, requiring two ligands-glutamate and glycine-for activation. These receptors function as heterotetrameric ion channels, with the channel opening dependent on the simultaneous binding of glycine and glutamate to the extracellular ligand-bindi ...[more]